PolyPheNOX

TM

polypheNOX™ is ten botanical extracts (Four with patents) formulated to deliver your diet’s daily cardiovascular supplement and exercise-boosting source of plant-based nitrates. Phytonitrates are nitric oxide precursors or donor actives. Nitric oxide whether produced internally or delivered through the diet in the form of phytonitrates, are requisite nutrients for optimal cell signaling, blood pressure regulation, blood composition and flowability, performance and energy production.

polypheNOX™ has the highest sources of dietary nitrates available, tested and then concentrated in a proprietary, solvent-free extraction method to provide the >6% phytonitrate, and >9% potassium specification for polypheNOX™.

Dietary nitrates delivered by polypheNOX™ are activated in the mouth and downstream in the stomach and absorbed directly into the bloodstream. As compared to the primary, endogenous pathway of delivering NO- to the tissues, eNOS (endothelial Nitric Oxide synthesis), the phytonitrate pathway is oxygen independent, and less apt to disruption by aging and chronic disease. The eNOS system requires an optimally working enzyme system, oxygen, and substrate precursors like arginine/citrulline, among other cofactors.

When healthy, the eNOS pathway can maintain a daily NO- requirement of ~0.05 grams/day in adults, including nitric oxide’s contribution to energy production, cardiovascular function, neurotransmission, immune defense and performance. However, when the eNOS system is impaired, such as with aging, low grade inflammation, oxidative stress, or a deficient diet (B2, B3, etc.), and/or low, daily fruit and vegetable consumption the body will suffer due to insufficient NO- availability. Similarly, intense utility of NO- such as in elite athletes, during extreme sports, or prolonged activity, can cause concomitant oxygen lack, that despite adequate arginine, will lead to a supply-and-demand mismatch. In the case of performance efforts, such shortage can interfere with continued output.

polypheNOX™can supplement the diet to support healthy blood pressure and cardiovascular health by taking up the slack of an impaired endothelial Nitric Oxide system (eNOS), while also helping to power intense exercise bouts, as an oxygen-independent route to more energy and greater performance.

Benefits:

  • Providessupport for healthy muscle recovery
  • Helpspromote muscle mass
  • Encouragesa healthy immune response with arginine
  • Promoteshealthy endothelial function
  • Supportsalready-healthy blood pressure levels
  • Encouragesnitric oxide production for healthy blood flow
  • Supportshealthy male sexual response
  • Helpsinhibit an enzyme that affects male sexual function
  • Support,normal healthy elasticity of arteries
  • Support,normal healthy elasticity of arteries
  • Promoteshealthy cellular energy
 

eNOS Pathway

Phytonitrate Pathway

Mechanism in NO Production

O2 + Arginine + eNOS——–NO-

Dietary nitrate (polypheNOX™) + Oral/stomach activity  nitrate  NO-

Constraints

Working eNOS enzymes, O2, Arginine/Citrulline, cofactors (BH4)

Vegetables & fruits, oral microbiome, and stomach pH

O2 Dependency

YES, O2 dependent, rate limiting

NO, Operates despite low oxygen state

Associated

Low grade inflammation, oxidative-

Plant-based nitrate intake (easily

Compromises

stress, aging, anaerobic exercise

and cardiovascular disease, etc.

augmented by polypheNOX™

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.